File Name: receptor signaling in caenorhabditis elegans modulates locomotion and egg laying.zip
Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Manual assertion based on experiment in i. This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped. Show all Align All. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
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PDF-mediated locomotion is regulated in neurons rather than in muscles. ▻ PDF signaling regulates egg-laying in Caenorhabditis elegans.
Egg-laying behavior has served as an important phenotypic assay for the genetic dissection of neuronal signal transduction mechanisms. This chapter reviews our current understanding of the neuronal and neurochemical mechanisms underlying the control of egg-laying in C. The roles of specific neurons in the egg-laying motor circuit, which release multiple neurotramsmitters affecting distinct parameters of egg-laying muscle activity, and the possible mechanisms for sensory control of egg-laying behavior, are discussed. Schafer, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Among the motor actions of which a nematode is capable, laying an egg is among the simplest.
Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools. Many predictions have been made about the number of C. In this review, we report the state of the art of both verified as well as predicted C. The predicted neuropeptide GPCRs are incorporated into the receptor classification system based on their resemblance to orthologous GPCRs in insects and vertebrates.
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying.
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Neurotransmitter and Neuropeptide Receptors in Caenorhabditis elegans Underlined items in this table contain links If table does not load in browser, it can also be viewed in Google Documents. By Zeynep F. Altun, to whom correspondence should be addressed.
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-. We isolated a PDF receptor loss-of-function allele lst34 by means of a.
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf We isolated a PDF receptor loss-of-function allele lst34 by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying. We demonstrate that the pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant and that pdf-1 and pdf-2 behave antagonistically. All three PDF receptor splice variants are involved in the regulation of locomotor behavior.
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